2,3,7,8-Tetrachlorodibenzo- p -dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice

Toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent, bioaccumulative and toxic contaminant widely distributed in the environment. Fishes are the most sensitive vertebrates to TCDD, especially during their early developmental stages. TCDD induces various toxic effects including yolk sac edema, craniofacial malformation and neural damage in developing fish embryos. However, the effects of ...

2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Anti-carcinogenic effects of the flavonoid luteolin.

Luteolin is a flavonoid which is part of our daily nutrition in relatively low amounts (less than 1 mg/day). Nevertheless, some epidemiological studies suggest an inverse correlation between luteolin intake and the risk of some cancer types. Luteolin displays specific anti-inflammatory and anti-carcinogenic effects, which can only partly be explained by its anti-oxidant and free radical scaveng...

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice.

It has been reported (1) that one effect of a single, intra-peritoneal dose of 2,3,7,8tetrachlorodibenzo-p-dioxin (dioxin) is to cause a reduction in the duration of action of the drug 2-amino-5-chlorobenzoxazole (zoxazolamine) in the rat. This effect is maximal with doses of dioxin above 100J,g/ kg and significant even at 5 jug/kg. Our own work showed that oral dosage had a similar effect but ...

Anti-carcinogenic effects of Satureja khuzistanica and Zataria multiflora essential oils on K562 cell line proliferation

The aim of this study was to investigate cytotoxic effect of Satureja khuzistanica and Zataria multiflora essential oils on PBMC and K562 cell lines growth inhibition. The plant essential oils were extracted by hydro-distillation and analyzed by GC-MS. In addition, the total phenol content and antioxidant activity of oils were assessed.  The PBMC and K562 cell lines were cultu...